Description

2,2,2-Trifluoro-1,1-diethoxyethane is a versatile fluorinated acetal building block. This compound is valued for its ability to introduce the trifluoroethyl moiety into target molecules, a key functional group in modern chemical synthesis. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of trifluoroethyl-containing drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the CF3 group enhances biological activity and metabolic stability.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and electronic materials requiring fluorinated segments.
• Organic Synthesis Reagent: Employed in nucleophilic addition and Grignard-type reactions to install the 2,2,2-trifluoroethoxy group.
• Cross-Coupling Chemistry: Acts as an electrophile in transition-metal catalyzed reactions for C-C bond formation.
• Asymmetric Synthesis: Used in chiral auxiliary or ligand-controlled reactions to create enantiomerically enriched fluorinated compounds.

Basic Information

Product Name	2,2,2-Trifluoro-1,1-Diethoxyethane
CAS No.	31224-45-0
Molecular Formula	C6H11F3O2
Molecular Weight	172.15 g/mol
Synonyms	1,1-Diethoxy-2,2,2-trifluoroethane; Ethane, 1,1-diethoxy-2,2,2-trifluoro-; 2,2,2-Trifluoroethyl Diethyl Acetal; Trifluoroacetaldehyde Diethyl Acetal; α,α,α-Trifluoroacetaldehyde Diethyl Acetal; Diethyl (2,2,2-Trifluoroethyl) Acetal; (2,2,2-Trifluoroethoxy)ethane
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoro-1,1-diethoxyethane is produced and tested under a strict quality management system. We ensure high chemical purity and lot-to-lot consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by GC or NMR), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.