Description

6-(Azidomethyl)-2,3-Dihydrobenzo[B][1,4]Dioxine Hydrochloride is a specialized organic building block featuring a benzodioxane scaffold functionalized with an azidomethyl group, supplied as its hydrochloride salt. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly in click chemistry applications via its reactive azide moiety. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active compounds and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS and cardiovascular diseases.
• Click Chemistry Reagent: The azide group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with alkynes, facilitating the rapid assembly of complex molecular architectures.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Polymer & Material Science: Used to functionalize polymers and surfaces, introducing specific chemical handles for further modification or cross-linking.
• Bioconjugation: Enables the labeling and modification of biomolecules (proteins, peptides, nucleic acids) for diagnostic and therapeutic applications.
• Chemical Biology Probes: Serves as a precursor for activity-based probes and other tools used to study biological processes.

Basic Information

Product Name	6-(Azidomethyl)-2,3-Dihydrobenzo[B][1,4]Dioxine Hydrochloride
CAS No.	31127-40-9
Molecular Formula	C9H9N3O2 • HCl
Molecular Weight	231.65 g/mol (Free base: 191.19 g/mol)
Synonyms	6-(Azidomethyl)-2,3-dihydro-1,4-benzodioxine hydrochloride; 1,4-Benzodioxin-6-methanol, α-azido-, hydrochloride; 6-(Azidomethyl)-1,4-benzodioxane hydrochloride; Azidomethylbenzodioxane HCl; 31127-40-9; 6-Azidomethyl-2,3-dihydrobenzo[b][1,4]dioxine HCl
EINECS	Contact for details

Quality Control

Our 6-(Azidomethyl)-2,3-Dihydrobenzo[B][1,4]Dioxine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key analytical parameters. Our quality systems are designed to meet the rigorous demands of advanced synthetic chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.