Description

2,6-Bis(Trimethylsilyloxy)Pyrimidine-4-Carboxylic Acid Trimethylsilyl Ester is a key silylated pyrimidine derivative, primarily valued as a versatile and protected synthetic intermediate in advanced organic synthesis. Its structure, featuring multiple trimethylsilyl (TMS) protecting groups, makes it crucial for facilitating specific reactions where sensitive functional groups must be shielded. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly in nucleoside and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside analogs, antiviral agents, and other pyrimidine-based active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that utilize a pyrimidine core structure.
• Advanced Material Precursor: Serves as a monomer or intermediate in the creation of specialty polymers and organic electronic materials.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes where the TMS groups act as protective agents for carboxylic acid and hydroxyl functionalities, enabling selective reactions.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new heterocyclic compounds and reaction methodologies.

Basic Information

Product Name	2,6-Bis(Trimethylsilyloxy)Pyrimidine-4-Carboxylic Acid Trimethylsilyl Ester
CAS No.	31111-36-1
Molecular Formula	C15H30N2O4Si3
Molecular Weight	386.66 g/mol
Synonyms	4-Carboxy-2,6-dihydroxypyrimidine tris(trimethylsilyl) ester; 2,6-Dihydroxypyrimidine-4-carboxylic Acid Tris(trimethylsilyl) Ester; Pyrimidine-4-carboxylic acid, 2,6-bis[(trimethylsilyl)oxy]-, trimethylsilyl ester; Tris-O-trimethylsilyl 2,6-dihydroxyisonicotinate; TMS-protected 2,6-dihydroxypyrimidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2,6-Bis(Trimethylsilyloxy)Pyrimidine-4-Carboxylic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.