Description

Trifluoroacetic Acid 3-Methoxyphenyl Ester is a specialized fluorinated aromatic ester used as a key synthetic intermediate and protecting group reagent. This compound is valued for its ability to introduce the trifluoroacetyl moiety, which can significantly alter the physicochemical properties of target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Protecting Group Chemistry: Acts as a protecting group for phenols during multi-step organic synthesis, with subsequent deprotection under mild conditions.
• Liquid Crystal & OLED Material Precursor: Used in the development of fluorinated organic electronic materials for displays and lighting applications.
• Peptide & Protein Modification: Facilitates the selective acylation of amino groups in peptide chemistry and bioconjugation strategies.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create biaryl structures.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, surface energy, or optical properties.
• Academic & Contract Research: A valuable reagent for methodological development and discovery chemistry in academic and industrial R&D laboratories.

Basic Information

Item	Details
Product Name	Trifluoroacetic Acid 3-Methoxyphenyl Ester
CAS No.	31083-16-6
Molecular Formula	C9H7F3O3
Molecular Weight	220.14 g/mol
Synonyms	3-Methoxyphenyl Trifluoroacetate; m-Methoxyphenyl Trifluoroacetate; Trifluoroacetic Acid m-Methoxyphenyl Ester; 3-Methoxyphenol Trifluoroacetate; 1-Methoxy-3-(trifluoroacetoxy)benzene; (3-Methoxyphenyl) 2,2,2-trifluoroacetate; TFA 3-Methoxyphenyl Ester; 31083-16-6
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid 3-Methoxyphenyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure consistency and reliability for your synthetic processes. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets your required grade, whether for research, pilot-scale, or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. The container should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.420 - 1.430
Density (g/mL at 20°C)	1.30 - 1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.