Description

n-α-Benzyloxycarbonyl-D-Alanine p-Nitrophenyl Ester is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is specifically designed to facilitate the controlled formation of peptide bonds, offering high reactivity and stereochemical purity. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical activated ester for the efficient coupling of D-alanine residues in automated and manual peptide assembly.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for constructing specific peptide sequences, particularly where D-amino acids are required.
• Pharmaceutical Intermediate: Serves as a key precursor in the research and development of peptide drugs, including antimicrobial peptides and hormone analogs.
• Bioconjugation: Employed to attach peptide motifs to other molecules, surfaces, or carriers for creating targeted drug delivery systems or diagnostic probes.
• Biochemical Research: Utilized in enzymology studies and for preparing enzyme substrates or inhibitors to investigate protease activity and specificity.
• Production of Custom Peptides: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide services.

Basic Information

Product Name	n-α-Benzyloxycarbonyl-D-Alanine p-Nitrophenyl Ester
CAS No.	30960-00-0
Molecular Formula	C17H16N2O6
Molecular Weight	344.32 g/mol
Synonyms	Z-D-Ala-ONp; Cbz-D-Ala-ONp; N-Carbobenzoxy-D-alanine 4-nitrophenyl ester; Benzyloxycarbonyl-D-alanine p-nitrophenyl ester; D-Alanine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; (R)-2-((((Benzyloxy)carbonyl)amino)propanoic acid 4-nitrophenyl ester; Z-D-Ala-ONp ester; CBZ-D-Alanine p-Nitrophenyl Ester
EINECS	Contact for details

Quality Control

Our n-α-Benzyloxycarbonyl-D-Alanine p-Nitrophenyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.