Description

(20R)-3α-Trimethylsilyloxy-17,20-[(Methylboranediyl)Bisoxy]-5β-Pregnane is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and protective silyl and boronate ester groups. This compound matters as a critical building block in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs), where precise molecular architecture is essential for biological activity. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries engaged in developing novel therapeutic agents.

Application

• Key Intermediate in Steroid Synthesis: Serves as a pivotal precursor in multi-step synthetic routes for producing pharmacologically active steroids and hormone analogs.
• Pharmaceutical R&D: Used in research and development for creating new drug candidates targeting hormonal pathways and related disorders.
• Process Chemistry: Employed in scale-up and process optimization studies for the commercial manufacturing of steroid APIs.
• Building Block for Boron-Containing Compounds: The methylboranediyl moiety makes it a valuable starting material for synthesizing other organoboron reagents used in cross-coupling reactions.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(20R)-3α-Trimethylsilyloxy-17,20-[(Methylboranediyl)Bisoxy]-5β-Pregnane
CAS No.	30882-48-5
Molecular Formula	C26H47BO4Si
Molecular Weight	462.55 g/mol
Synonyms	3α-(Trimethylsilyloxy)-17,20-[(methylboranediyl)bis(oxy)]-5β-pregnane (20R)-; 5β-Pregnane-3α-ol, 17,20-[(methylboranediyl)bis(oxy)]-, 3-(trimethylsilyl) ether, (17R,20R)-; (20R)-17,20-[(Methylboranediyl)bis(oxy)]-3α-(trimethylsilyloxy)-5β-pregnane; Pregnane boronic ester silyl ether derivative; Steroid boronate intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (20R)-3α-Trimethylsilyloxy-17,20-[(Methylboranediyl)Bisoxy]-5β-Pregnane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) and handle in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.