Description

Trimethylsilylmethyl Isocyanide is a versatile organosilicon reagent featuring a reactive isocyanide functional group. This compound is valued for its role as a key building block in the synthesis of complex heterocycles and functionalized molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for constructing heterocyclic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science Research: Employed in the preparation of functionalized polymers and advanced organic materials with tailored properties.
• Multi-Component Reactions (MCRs): Serves as a key component in Passerini and Ugi-type reactions for the efficient, one-pot generation of compound libraries.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Peptidomimetics and Bio-conjugates: Facilitates the introduction of isocyanide functionality into peptides and biomolecules for further derivatization.

Basic Information

Product Name	Trimethylsilylmethyl Isocyanide
CAS No.	30718-17-3
Molecular Formula	C5H11NSi
Molecular Weight	113.23 g/mol
Synonyms	Isocyanomethyltrimethylsilane; (Isocyanomethyl)trimethylsilane; Trimethylsilylmethyl isonitrile; TMSMNC; (Trimethylsilyl)methyl isocyanide; NSC 163063; Trimethyl(isocyanomethyl)silane
EINECS	Contact for details

Quality Control

Our Trimethylsilylmethyl Isocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated area. Keep away from heat, sparks, and open flame. Due to its sensitivity, allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.