Description

[R,(-)]-1-O,2-o-Dipalmitoyl-3-o-Trityl-D-Glycerol is a high-purity, chiral glycerol derivative that serves as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in its protected glycerol backbone, which allows for the stereoselective synthesis of complex lipids, phospholipids, and prodrugs. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical industries who require precise building blocks for lipid-based drug delivery systems, vaccine adjuvants, and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of phospholipids, lysophospholipids, and other glycerophospholipids used in drug formulations.
• Lipid Nanoparticle (LNP) Research: Serves as a foundational building block in the development and optimization of ionizable lipids and other components for mRNA and siRNA delivery systems.
• Prodrug Synthesis: Utilized in the design and creation of lipid-conjugated prodrugs to enhance drug solubility, bioavailability, and targeted delivery.
• Bioconjugation Chemistry: The protected trityl and palmitoyl groups provide orthogonal reactivity for selective functionalization in complex biomolecule conjugation.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in lipid analysis (e.g., HPLC, MS).
• Biomimetic Membrane Studies: Employed in the synthesis of model lipids for studying membrane biophysics, protein-lipid interactions, and cell signaling pathways.

Basic Information

Product Name	[R,(-)]-1-O,2-o-Dipalmitoyl-3-o-Trityl-D-Glycerol
CAS No.	30563-16-7
Molecular Formula	C72H108O5
Molecular Weight	1053.61 g/mol
Synonyms	1,2-Dipalmitoyl-3-trityl-sn-glycerol; (R)-1,2-Dihexadecanoyl-3-tritylglycerol; D-Trityl-1,2-dipalmitoylglycerol; 3-O-Trityl-1,2-di-O-palmitoyl-sn-glycerol; sn-Glycerol 1,2-dipalmitate 3-trityl ether; (-)-1,2-Dipalmitoyl-3-tritylglycerol; 30563-16-7; 1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol
EINECS	Contact for details

Quality Control

Our [R,(-)]-1-O,2-o-Dipalmitoyl-3-o-Trityl-D-Glycerol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.