Description

4-Methoxy-Benzoic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester is a high-purity active ester derivative of p-anisic acid, specifically designed as a versatile and reactive acylating agent for peptide synthesis and other advanced organic transformations. Its core value lies in its ability to facilitate efficient amide bond formation under mild conditions, offering superior reactivity and selectivity for demanding synthetic protocols. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable building blocks for complex molecule assembly.

Application

• Peptide Synthesis: Serves as a key activated ester intermediate for the coupling of p-anisic acid (4-methoxybenzoic acid) in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: Used for the selective modification of proteins, antibodies, and other biomolecules by introducing the 4-methoxybenzoyl moiety.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent in the synthesis of specialty polyamides and other functional polymers.
• Pharmaceutical Intermediates: A critical building block in the multistep synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science: Utilized in surface functionalization and the creation of advanced organic materials with specific optical or electronic properties.

Basic Information

Product Name	4-Methoxy-Benzoic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester
CAS No.	30364-57-9
Molecular Formula	C13H13NO5
Molecular Weight	263.25 g/mol
Synonyms	4-Methoxybenzoic Acid N-Hydroxysuccinimide Ester; p-Anisic Acid N-Succinimidyl Ester; N-Succinimidyl 4-Methoxybenzoate; NHS ester of 4-Methoxybenzoic Acid; 4-Methoxybenzoyloxy-2,5-pyrrolidinedione; 1-[(4-Methoxybenzoyl)oxy]-2,5-pyrrolidinedione; NSC 334358; Succinimidyl 4-methoxybenzoate
EINECS	Contact for details

Quality Control

Our 4-Methoxy-Benzoic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.