Description

(S)-(-)-2-Isocyanatopropionic Acid Methyl Ester is a high-purity, chiral isocyanate derivative essential for introducing the (S)-2-isocyanopropionyl moiety into target molecules. This compound matters as a key chiral building block for the synthesis of enantiomerically pure pharmaceuticals and advanced agrochemicals, where stereochemistry is critical for biological activity. It is needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Used in the preparation of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other small molecule drugs.
• Agrochemical Building Block: Serves as a precursor for the synthesis of chiral herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Peptide Mimetics and Bioconjugation: Employed to incorporate the isocyanato group into peptide backbones or for site-specific labeling of biomolecules.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for producing specialty polymers with tailored properties.
• Asymmetric Catalyst Ligand Synthesis: Utilized in the construction of chiral ligands for metal-catalyzed asymmetric reactions.
• Chemical Biology Probes: A valuable reagent for creating activity-based probes to study enzyme function and mechanism.

Basic Information

Product Name	(S)-(-)-2-Isocyanatopropionic Acid Methyl Ester
CAS No.	30293-82-4
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	(S)-2-Isocyanatopropionic Acid Methyl Ester; Methyl (S)-2-Isocyanatopropionate; (S)-Methyl 2-Isocyanatopropanoate; L-2-Isocyanatopropionic Acid Methyl Ester; (S)-(-)-Methyl 2-Isocyanopropionate; (S)-Methyl α-Isocyanatopropionate; Methyl (S)-(-)-2-isocyanatopropanoate; NSC 163066
EINECS	Contact for details

Quality Control

Our (S)-(-)-2-Isocyanatopropionic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and incompatible materials such as water, alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.