Description

2-Trimethylsilylethynyltoluene is a specialized organosilicon building block featuring a trimethylsilyl-protected acetylene group attached to a toluene core. This compound is valued for its role as a versatile synthon in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the acetylene moiety is incorporated into bioactive molecules.
• Material Science & OLED Development: Serves as a building block for creating conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Academic & Industrial R&D: Employed in laboratory-scale research for method development and the exploration of new chemical entities across various chemistry disciplines.
• Ligand & Catalyst Preparation: Useful in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-Trimethylsilylethynyltoluene
CAS No.	3989-15-9
Molecular Formula	C₁₂H₁₆Si
Molecular Weight	188.34 g/mol
Synonyms	Toluene, 2-[(trimethylsilyl)ethynyl]-; 2-(Trimethylsilylethynyl)toluene; 2-Methylphenyl(trimethylsilyl)acetylene; o-Methylphenyl(trimethylsilyl)acetylene; 2-((Trimethylsilyl)ethynyl)toluene; TMS-protected o-ethynyltoluene
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilylethynyltoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.