Description

(4-Methoxyphenylethynyl)Trimethylsilane is a versatile organosilicon building block featuring a protected alkynyl group. This compound is valued for its role in advanced organic synthesis, particularly in cross-coupling and cycloaddition reactions to construct complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those requiring arylacetylene motifs.
• Agrochemical Synthesis: Used in constructing bioactive molecules for crop protection agents and herbicides.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis.
• Organic Synthesis Building Block: Utilized in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to introduce the 4-methoxyphenylacetylene unit.
• Research & Development: A valuable reagent for academic and industrial R&D in synthetic methodology and medicinal chemistry.

Basic Information

Product Name	(4-Methoxyphenylethynyl)Trimethylsilane
CAS No.	3989-14-8
Molecular Formula	C₁₂H₁₆OSi
Molecular Weight	204.34 g/mol
Synonyms	1-[(Trimethylsilyl)ethynyl]-4-methoxybenzene; 4-Methoxyphenylethynyltrimethylsilane; p-Methoxyphenylethynyltrimethylsilane; Trimethyl[(4-methoxyphenyl)ethynyl]silane; 4-Methoxybenzeneacetylene trimethylsilyl derivative; (p-Methoxyphenyl)ethynyltrimethylsilane; 4-Methoxyphenylacetylene trimethylsilyl ether; TMS-protected 4-ethynylanisole
EINECS	Contact for details

Quality Control

Our (4-Methoxyphenylethynyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.