Description

(3-Bromophenylethynyl)Trimethylsilane is a high-purity organosilicon building block featuring a brominated aromatic alkyne moiety protected by a trimethylsilyl (TMS) group. This compound matters as a versatile and critical intermediate in advanced organic synthesis, particularly for Sonogashira and other cross-coupling reactions, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing acetylene-linked aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides that require specific bromo-alkyne functionalities.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers where the conjugated alkyne unit is essential for electronic properties.
• Cross-Coupling Reactions: An essential substrate for Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Used to synthesize novel phosphine or N-heterocyclic carbene (NHC) ligands with tailored steric and electronic properties.
• Chemical Biology Probes: Facilitates the synthesis of tagged molecules and probes for studying biological processes via click chemistry methodologies.

Basic Information

Product Name	(3-Bromophenylethynyl)Trimethylsilane
CAS No.	3989-13-7
Molecular Formula	C11H13BrSi
Molecular Weight	253.21 g/mol
Synonyms	1-Bromo-3-[(trimethylsilyl)ethynyl]benzene; 3-Bromophenyl(trimethylsilyl)acetylene; Trimethyl[(3-bromophenyl)ethynyl]silane; 3-Bromo-1-[(trimethylsilyl)ethynyl]benzene; 3-Bromophenylethynyltrimethylsilane; (3-Bromophenyl)ethynyltrimethylsilane; TMS-Protected 3-Bromophenylacetylene
EINECS	Contact for details

Quality Control

Our (3-Bromophenylethynyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.