Description

4-Fluorobenzenesulfonyl Isocyanate is a highly reactive organosulfur compound characterized by its sulfonyl isocyanate functional group. This specialized reagent is critical for introducing the 4-fluorobenzenesulfonyl (or tosyl-like) moiety into target molecules, enabling the synthesis of sulfonylureas, sulfonylcarbamates, and other valuable intermediates. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonylurea and sulfonylcarbamate-based drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, pesticides, and plant growth regulators that incorporate a sulfonyl isocyanate pharmacophore.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialized polymers with unique thermal or chemical resistance properties.
• Chemical Derivatization: Employed in analytical chemistry to derivative amines, alcohols, and other nucleophiles for detection, separation, or purification purposes.
• Material Science Research: Facilitates the surface modification of materials and the creation of advanced coatings with tailored functionalities.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	4-Fluorobenzenesulfonyl Isocyanate
CAS No.	3895-25-8
Molecular Formula	C7H4FNO3S
Molecular Weight	201.17 g/mol
Synonyms	p-Fluorobenzenesulfonyl isocyanate; 4-Fluorophenylsulfonyl isocyanate; Benzenesulfonyl isocyanate, 4-fluoro-; 1-Fluoro-4-(isocyanatosulfonyl)benzene; 4-Fluoro-benzenesulfonyl isocyanate; NSC 163081; 4-FBSI
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzenesulfonyl Isocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from techniques such as HPLC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and should be allowed to reach room temperature before opening to prevent moisture ingress. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.