Description

Trifluoromethanesulfonyl Azide is a highly versatile and reactive reagent used as a key synthon for introducing azide and triflyl functionalities. Its primary value lies in its role as a powerful precursor for click chemistry and cycloaddition reactions, enabling efficient synthesis of complex heterocycles and functionalized molecules. This compound is essential for researchers and process chemists in pharmaceutical development, agrochemical research, and advanced materials science, where precise molecular construction is critical.

Application

• Click Chemistry Reagent: A crucial building block for Huisgen 1,3-dipolar cycloaddition reactions to form 1,2,3-triazoles.
• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly those containing triazole or sulfonamide moieties.
• Agrochemical Synthesis: Employed in creating advanced active ingredients for crop protection products.
• Polymer & Materials Science: Facilitates the functionalization of polymers and surfaces via azide-alkyne coupling.
• Peptide Modification: Enables site-specific labeling and conjugation of biomolecules.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts.

Basic Information

Product Name	Trifluoromethanesulfonyl Azide
CAS No.	3855-45-6
Molecular Formula	CF3N3O2S
Molecular Weight	175.09 g/mol
Synonyms	Triflyl Azide; Trifluoromethanesulfonic Azide; Trifluoromethylsulfonyl Azide; TfN3; Trifluoromethanesulphonyl Azide; Azidotrifluoromethanesulfonate; 1-Azido-1,1-difluoro-2,2,2-trifluoroethanesulfonate
EINECS	223-363-8

Quality Control

Our Trifluoromethanesulfonyl Azide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our customers in research and cGMP-compliant development environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, ideally at 2-8°C. Handle and store under an inert atmosphere to maintain stability and prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.