Description

1-Trimethylsilyl-1-Hexyne is a versatile organosilicon compound featuring a terminal alkyne group protected by a trimethylsilyl (TMS) moiety. This functional group combination makes it a valuable building block in organic synthesis, particularly for cross-coupling reactions and the construction of complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Serves as a key precursor for creating novel compounds with potential herbicidal or insecticidal activity.
• Material Science: Employed in the development of organic semiconductors, liquid crystals, and polymers where the alkyne functionality is crucial.
• Organic Synthesis Reagent: Acts as a protected acetylene equivalent, allowing for the selective introduction of alkynyl groups in multi-step synthetic sequences.
• Chemical Research: Utilized in academic and industrial R&D for methodology development and the exploration of new chemical spaces.

Basic Information

Product Name	1-Trimethylsilyl-1-Hexyne
CAS No.	3844-94-8
Molecular Formula	C9H18Si
Molecular Weight	154.33 g/mol
Synonyms	Hex-1-yn-1-yltrimethylsilane; Trimethyl(1-hexyn-1-yl)silane; 1-Hexyne, 1-trimethylsilyl-; TMS-1-Hexyne; (Hex-1-ynyl)trimethylsilane; 1-(Trimethylsilyl)-1-hexyne; Silane, trimethyl(1-hexyn-1-yl)-
EINECS	223-352-2

Quality Control

Our 1-Trimethylsilyl-1-Hexyne is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.