Description

3α-(Trifluoroacetyloxy)-5β-Cholan-24-Oic Acid Methyl Ester is a high-purity, synthetic steroidal derivative of cholic acid, modified with a trifluoroacetyl group. This compound is a critical advanced pharmaceutical intermediate (API intermediate) used in the synthesis of complex bioactive molecules. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers working on steroid-based therapeutics, metabolic research, and novel drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of bile acid analogs and steroidal drugs.
• Metabolic Research: Used as a probe or standard in studies investigating cholesterol metabolism and bile acid pathways.
• Medicinal Chemistry: Serves as a versatile scaffold for the development of new chemical entities targeting nuclear receptors like FXR (Farnesoid X receptor).
• Bioconjugation: The reactive ester group facilitates its use in labeling and conjugation strategies for biochemical applications.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for complex steroidal compounds.

Basic Information

Product Name	3α-(Trifluoroacetyloxy)-5β-Cholan-24-Oic Acid Methyl Ester
CAS No.	3793-41-7
Molecular Formula	C₂₇H₄₁F₃O₄
Molecular Weight	486.61 g/mol
Synonyms	Methyl 3α-(Trifluoroacetoxy)-5β-cholan-24-oate; 3α-Trifluoroacetoxy-5β-cholan-24-oic Acid Methyl Ester; Methyl 3α-Trifluoroacetoxy-5β-cholanoate; 5β-Cholan-24-oic Acid, 3α-(Trifluoroacetyloxy)-, Methyl Ester; Trifluoroacetic Acid 3α-Hydroxy-5β-cholan-24-oic Acid Methyl Ester Ester; Cholic Acid Methyl Ester 3-Trifluoroacetate; 3α-TFA-5β-Cholan-24-oic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 3α-(Trifluoroacetyloxy)-5β-Cholan-24-Oic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and IR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.