Description

Triethyl 3-Phosphonopropionate is a high-purity organophosphorus compound, specifically a phosphonate ester, widely recognized as a key building block in organic synthesis. Its primary value lies in its role as a versatile reagent for the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient and stereoselective synthesis of α,β-unsaturated esters. This makes it an indispensable material for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediates: Critical for synthesizing key intermediates in active pharmaceutical ingredients (APIs), particularly those containing α,β-unsaturated carbonyl moieties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require specific alkene geometries.
• Fine Chemical Manufacturing: Serves as a fundamental reagent for constructing complex organic molecules in custom synthesis and process development.
• Material Science Research: Employed in the synthesis of monomers and functional polymers with tailored properties.
• Academic & Industrial R&D: A staple reagent in laboratories for method development and the synthesis of novel chemical entities.

Basic Information

Product Name	Triethyl 3-Phosphonopropionate
CAS No.	3699-67-0
Molecular Formula	C9H19O5P
Molecular Weight	238.22 g/mol
Synonyms	(Triethoxyphosphoryl)propanoic Acid Ethyl Ester; Ethyl 3-(Diethoxyphosphoryl)propionate; Triethyl (2-Carbethoxyethyl)phosphonate; 3-(Diethoxyphosphoryl)propionic Acid Ethyl Ester; (2-Carbethoxyethyl)phosphonic Acid Triethyl Ester; Phosphonopropionic Acid Triethyl Ester; HWE Reagent
EINECS	223-036-4

Quality Control

Our Triethyl 3-Phosphonopropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assessment and identity confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The product is moisture-sensitive; ensure containers are kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.435
Density (20°C)	1.10 - 1.15 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.