Description

4-Chloro-2-Picoline is a versatile chlorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of pharmaceuticals, agrochemicals, and functional materials, enabling precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, crop protection, and specialty chemical industries for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Agrochemical Synthesis: Building block for manufacturing advanced herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Used to create novel pyridine-based ligands for transition metal catalysis.
• Material Science: Intermediate in the production of functional polymers and electronic chemicals.
• Organic Synthesis: Versatile reagent for introducing the 2-picolyl moiety with a chloro handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Negishi).
• Research & Development: Standard reagent in academic and industrial labs for method development and novel compound library synthesis.

Basic Information

Product Name	4-Chloro-2-Picoline
CAS No.	3678-63-5
Molecular Formula	C6H6ClN
Molecular Weight	127.57 g/mol
Synonyms	4-Chloro-2-methylpyridine; 2-Methyl-4-chloropyridine; 4-Chloro-2-picoline; 4-Chloro-2-methylpyridine; 2-Picoline, 4-chloro-; 4-Chloro-2-methylpyridine (principal synonym); 4-Chloro-2-picoline; 2-Methyl-4-chloro-pyridine
EINECS	222-955-5

Quality Control

Our 4-Chloro-2-Picoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.