Description

Bis(Trimethylsilyl) Phosphite CAS NO 3663-52-3 is a versatile organosilicon reagent primarily used as a silylating agent and a key intermediate in organic synthesis. Its core value lies in its ability to introduce the trimethylsilyl (TMS) group, which serves as a protective group for sensitive functional groups like phosphites and alcohols, enabling complex multi-step synthetic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for developing active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs) where phosphorus-containing moieties are required.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators that incorporate phosphonate or phosphate ester functionalities.
• Polymer & Material Science: Serves as a monomer or modifying agent in the creation of flame-retardant polymers, specialty silicones, and other high-performance materials.
• Peptide & Oligonucleotide Chemistry: Employed as a phosphitylating agent in solid-phase synthesis for the protection of phosphate groups during the assembly of oligonucleotides and related biomolecules.
• Catalyst & Ligand Preparation: Acts as a precursor for synthesizing organophosphorus ligands used in homogeneous catalysis and transition metal complexes.
• Laboratory Reagent: Utilized as a versatile silylating and phosphorylating reagent in research-scale organic synthesis and process development.

Basic Information

Product Name	Bis(Trimethylsilyl) Phosphite
CAS No.	3663-52-3
Molecular Formula	C6H19O3PSi2
Molecular Weight	226.36 g/mol
Synonyms	Phosphorous Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) Phosphonate; Hexamethyldisilyl Phosphite; TMS-Phosphite; (Trimethylsilyl) Phosphite; O,O-Bis(trimethylsilyl) Hydrogen Phosphonite; Phosphonic Acid, Bis(trimethylsilyl) Ester; HMDS-Phosphite
EINECS	222-902-7

Quality Control

Our Bis(Trimethylsilyl) Phosphite is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong oxidizers and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Chloride (as Cl)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.