Description

Isopropyldimethylchlorosilane is a versatile organosilicon reagent featuring a reactive chlorosilane group and an isopropyl substituent. This compound is a critical intermediate for introducing the isopropyldimethylsilyl (IPDMS) protecting group in sophisticated organic synthesis, particularly for sensitive alcohols and polyols. It is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity silanes for precise molecular construction and surface modification.

Application

• Protecting Group Reagent: Primary application for the selective protection of hydroxyl groups in complex multi-step syntheses of pharmaceuticals, natural products, and fine chemicals.
• Pharmaceutical Intermediate: Used in the production of active pharmaceutical ingredients (APIs) where temporary protection of sensitive functional groups is required.
• Surface Modification Agent: Employed to functionalize silica, glass, and other inorganic surfaces, altering their hydrophobicity and reactivity for chromatography or composite materials.
• Silicone Chemistry: Serves as a monomer or capping agent in the synthesis of specialty silicone polymers and resins with tailored properties.
• Agrochemical Synthesis: Utilized in the manufacture of advanced pesticides and herbicides that require silane-based intermediates.
• Cross-coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling and other metal-mediated transformations.

Basic Information

Product Name	Isopropyldimethylchlorosilane
CAS No.	3634-56-8
Molecular Formula	C5H13ClSi
Molecular Weight	136.70 g/mol
Synonyms	Chloroisopropyldimethylsilane; Isopropyldimethylsilyl Chloride; (Chlorodimethylsilyl)propane; IPDMSCI; Dimethylisopropylsilyl Chloride; 1-Chloro-1-isopropyl-1,1-dimethyldisilane; (Dimethylchlorosilyl)propane; EINECS 222-874-0
EINECS	222-874-0

Quality Control

Our Isopropyldimethylchlorosilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat and ignition sources. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	0.86 - 0.88 g/mL
Refractive Index (n20D)	1.410 - 1.415
Boiling Point	Approx. 105-108°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.