Description

Etofibrate 2-Hydroxymethylnicotinate CAS NO 3612-80-4 is a high-purity chemical intermediate of significant importance in advanced pharmaceutical synthesis. This compound serves as a crucial building block for the development of active pharmaceutical ingredients (APIs), particularly in the lipid-regulating drug class. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in producing sophisticated therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of etofibrate and related fibrate-class lipid-modulating agents.
• Active Pharmaceutical Ingredient (API) Development: Used in research and scale-up for new chemical entities targeting dyslipidemia.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex organic molecules with potential biological activity.
• Biochemical Research: Employed in metabolic and pharmacological studies to investigate mechanisms of action for hypolipidemic drugs.
• Contract Manufacturing: Supplied to CDMOs for the production of generic or proprietary pharmaceutical formulations.
• Reference Standard: Can be utilized as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Etofibrate 2-Hydroxymethylnicotinate
CAS No.	3612-80-4
Molecular Formula	C15H14ClNO5
Molecular Weight	323.73 g/mol
Synonyms	2-(Hydroxymethyl)pyridine-3-carboxylic acid 2-(4-chlorophenoxy)-2-methylpropanoate; 2-Hydroxymethylnicotinic acid clofibrate ester; Etofibrate nicotinate; Etofibrate 2-hydroxymethylnicotinate; Clofibrate 2-hydroxymethylnicotinate; 3-Pyridinecarboxylic acid, 2-(hydroxymethyl)-, 2-(4-chlorophenoxy)-2-methylpropyl ester; 2-(4-Chlorophenoxy)-2-methylpropyl 2-(hydroxymethyl)nicotinate
EINECS	Contact for details

Quality Control

Our Etofibrate 2-Hydroxymethylnicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.