Description

4’－Demethyldeoxypodophyllotoxin is a high-purity, semi-synthetic lignan derivative and a key intermediate in the synthesis of potent chemotherapeutic agents. This compound matters significantly for its role as a critical precursor in the development of novel anti-cancer drugs, particularly etoposide and teniposide analogs, due to its specific structural configuration. Pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in oncology drug discovery are the primary users who need this high-value intermediate for their synthetic and biological evaluation programs.

Application

• Pharmaceutical Intermediate: A crucial building block for the semi-synthesis of podophyllotoxin-derived chemotherapeutic agents like etoposide and teniposide.
• Oncology Research: Used in medicinal chemistry programs to develop and evaluate new anti-cancer compounds targeting topoisomerase II.
• Biochemical Tool: Serves as a reference standard and probe in studies investigating cell cycle arrest and apoptosis mechanisms.
• Fine Chemical Synthesis: Employed in advanced organic synthesis to create novel lignan-based libraries for biological screening.
• Academic Research: Utilized in university and institutional labs for pharmacological and phytochemical studies.

Basic Information

Product Name	4’－Demethyldeoxypodophyllotoxin
CAS No.	3590-93-0
Molecular Formula	C21H20O7
Molecular Weight	384.38 g/mol
Synonyms	4'-Demethyldeoxypodophyllotoxin; 4'-Demethyl-desoxypodophyllotoxin; NSC 335153; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Deoxypicropodophyllin 4'-methyl ether derivative; 4'-Desmethyldeoxypodophyllotoxin
EINECS	Contact for details

Quality Control

Our 4’－Demethyldeoxypodophyllotoxin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom synthesis to meet specific pharmacopeial or client specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.