Description

1-(Trimethylsilyl)Piperidine-2-One is a specialized organosilicon compound that serves as a versatile building block and protecting group reagent in advanced synthetic chemistry. Its value lies in its ability to impart unique reactivity and stability to intermediates, facilitating complex molecular transformations. This high-purity chemical is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing piperidine or lactam motifs.
• Organosilicon Chemistry: Used as a silylating agent to introduce the trimethylsilyl (TMS) protecting group for amines or alcohols in multi-step synthesis.
• Agrochemical Research: Employed in the development of new pesticides and herbicides where the silylated lactam structure offers specific biological activity or stability.
• Material Science Precursor: Acts as a monomer or modifying agent in the production of specialized silicon-containing polymers and advanced materials.
• Chemical Synthesis Reagent: Facilitates various organic transformations, including ring-opening reactions and as a precursor to other functionalized piperidine derivatives.

Basic Information

Product Name	1-(Trimethylsilyl)Piperidine-2-One
CAS No.	3553-93-3
Molecular Formula	C8H17NOSi
Molecular Weight	171.31 g/mol
Synonyms	1-(Trimethylsilyl)-2-piperidinone; 2-Piperidinone, 1-(trimethylsilyl)-; N-Trimethylsilyl-2-piperidinone; 1-Trimethylsilylpiperidin-2-one; N-(Trimethylsilyl)-2-piperidinone; 1-TMS-piperidin-2-one; 3553-93-3; Piperidine-2-one, 1-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)Piperidine-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.