Description

(5-Methyl-1,3-Bis-Trimethylsilyl)-2,4-(1H,3H-Pyrimidinedione) CAS NO 3444-09-5 is a silylated pyrimidinedione derivative, a key protected intermediate in organic synthesis. Its primary value lies in providing a reactive, moisture-sensitive building block for constructing complex heterocyclic compounds, particularly in nucleoside and pharmaceutical chemistry. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors who require high-purity, specialized intermediates.

Application

• Pharmaceutical Intermediate: A crucial protected synthon for the synthesis of modified nucleosides, nucleotides, and related antiviral or anticancer agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators based on pyrimidine scaffolds.
• Organic Synthesis Building Block: Serves as a versatile intermediate for introducing the 5-methyl-2,4-pyrimidinedione moiety into larger molecular architectures under controlled conditions.
• Material Science Research: Employed in the development of specialty polymers, ligands, or organic electronic materials where specific heterocyclic units are required.
• Process Chemistry: Used in scale-up and optimization of synthetic routes that require the temporary protection of reactive sites on the pyrimidinedione core.

Basic Information

Product Name	(5-Methyl-1,3-Bis-Trimethylsilyl)-2,4-(1H,3H-Pyrimidinedione)
CAS No.	3444-09-5
Molecular Formula	C12H24N2O2Si2
Molecular Weight	284.50 g/mol
Synonyms	1,3-Bis(trimethylsilyl)-5-methyluracil; 5-Methyl-1,3-bis(trimethylsilyl)uracil; 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine; 5-Methyl-N,N'-bis(trimethylsilyl)isocytosine; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-1,3-bis(trimethylsilyl)-; 5-Methyl-1,3-bis-O-(trimethylsilyl)uracil; TMS-protected 5-methyluracil
EINECS	Contact for details

Quality Control

Every batch of our (5-Methyl-1,3-Bis-Trimethylsilyl)-2,4-(1H,3H-Pyrimidinedione) is produced and tested under strict quality management protocols. We ensure high chemical purity and consistency suitable for demanding research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.