Description

Estradiol Diacetate is a synthetic, lipophilic ester derivative of the natural estrogen hormone, estradiol. This compound is valued for its enhanced stability and controlled release profile compared to the parent hormone, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily utilized by manufacturers in the pharmaceutical and life science research sectors for the development of hormone therapies and as a key reference standard in analytical laboratories.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of steroidal drugs and hormone replacement therapies (HRT).
• Research & Development: Used as a reference standard and biochemical tool in endocrinology and pharmacology research.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a precursor in the production of specific estrogen-based APIs.
• Veterinary Medicine: Employed in the formulation of hormonal treatments for animals.
• Controlled-Release Formulations: Its diacetate form is leveraged in drug delivery systems designed for sustained release.

Basic Information

Product Name	Estradiol Diacetate
CAS No.	3434-88-6
Molecular Formula	C22H28O4
Molecular Weight	356.46 g/mol
Synonyms	Estradiol 3,17-Diacetate; 3,17β-Diacetoxyestra-1,3,5(10)-triene; Estr-1,3,5(10)-triene-3,17β-diol diacetate; 17β-Estradiol diacetate; Diacetoxyestradiol; NSC 20264; Oestradiol Diacetate
EINECS	222-337-4

Quality Control

Our Estradiol Diacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets stringent specifications for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.