Description

Trimethyl-Propan-2-Yl-Silane is a versatile organosilicon compound, specifically a silyl ether, known for its utility as a key protecting group reagent and synthetic intermediate in advanced organic synthesis. Its primary value lies in its ability to introduce the robust tert-butyldimethylsilyl (TBDMS) protecting group, which is crucial for the selective protection of alcohols and other functional groups under mild conditions. This makes it an indispensable material for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for complex, multi-step synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent for introducing the tert-butyldimethylsilyl (TBDMS) protecting group for hydroxyl functions in the synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules.
• Agrochemical Production: Serves as a vital building block in the synthesis of advanced pesticides, herbicides, and plant growth regulators where selective protection is required.
• Fine Chemical & Specialty Chemical Manufacturing: Employed in the production of fragrances, flavors, dyes, and other high-value specialty chemicals requiring sophisticated synthetic pathways.
• Academic & Industrial R&D: A staple reagent in research laboratories for method development, process chemistry, and the synthesis of novel organic compounds and materials.
• Polymer & Material Science: Can be utilized as a modifier or cross-linking agent in the development of specialty silicones and silicon-containing polymers.
• Nucleoside & Carbohydrate Chemistry: Critical for the protection of sugar alcohols and nucleosides during oligonucleotide and carbohydrate synthesis.

Basic Information

Product Name	Trimethyl-Propan-2-Yl-Silane
CAS No.	3429-52-5
Molecular Formula	C7H18Si
Molecular Weight	130.30 g/mol
Synonyms	tert-Butyldimethylsilane; TBDMS-H; (1,1-Dimethylethyl)dimethylsilane; tert-Butyldimethylsilyl Hydride; Dimethyl(tert-butyl)silane; 2-(Dimethylsilyl)-2-methylpropane; tert-C4H9SiH(CH3)2
EINECS	222-329-8

Quality Control

Our Trimethyl-Propan-2-Yl-Silane is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy, to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	0.70 - 0.72 g/mL
Refractive Index (n20D)	1.405 - 1.410

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.