Description

n-[(Benzyloxy)Carbonyl]-L-Glutamic Acid 5-(1,1-Dimethylethyl)1-(2,4,5-Trichlorophenyl) Ester is a sophisticated, high-purity protected amino acid derivative designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise molecular building blocks for complex peptide synthesis and pharmaceutical intermediate production. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), specialized peptide drugs, and as a key reagent in medicinal chemistry research.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex peptide-based Active Pharmaceutical Ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the Cbz (Carbobenzyloxy) protecting group and tert-butyl ester are required for specific side-chain protection strategies.
• Medicinal Chemistry & Drug Discovery: Serves as a key reagent for constructing glutamic acid analogs and exploring structure-activity relationships (SAR) in new drug candidates.
• Bioconjugation & Probe Development: Employed in the synthesis of labeled peptides and molecular probes for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, non-commercial compounds under cGMP conditions.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Glutamic Acid 5-(1,1-Dimethylethyl)1-(2,4,5-Trichlorophenyl) Ester
CAS No.	3405-82-1
Molecular Formula	C23H24Cl3NO5
Molecular Weight	500.79 g/mol
Synonyms	N-Carbobenzyloxy-L-glutamic acid 5-tert-butyl 1-(2,4,5-trichlorophenyl) ester; Cbz-L-Glu(OtBu)-O-(2,4,5-Trichlorophenyl); Z-L-Glutamic acid 5-(1,1-dimethylethyl) 1-(2,4,5-trichlorophenyl) ester; L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) 1-(2,4,5-trichlorophenyl) ester; Z-Glu(OtBu)-OPcp; CBZ-GLU(OTBU)-OPCP; (2S)-2-[(Benzyloxy)carbonylamino]pentanedioic acid 5-tert-butyl ester 1-(2,4,5-trichlorophenyl) ester
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Glutamic Acid 5-(1,1-Dimethylethyl)1-(2,4,5-Trichlorophenyl) Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines and can supply material that meets the stringent requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided per COA
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%
Single Impurity (HPLC)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.