Description

Z-Pro-Osu CAS NO 3397-33-9 is a high-purity, protected amino acid derivative widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over stereochemistry and reaction pathways in complex organic and medicinal chemistry. It is primarily utilized by the pharmaceutical, biotechnology, and advanced chemical research sectors for developing novel therapeutic peptides and fine chemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled, sequential coupling of proline residues, ensuring high coupling efficiency and minimizing racemization.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptide sequences and cyclic peptides where traditional coupling agents may be less effective.
• Medicinal Chemistry & Drug Discovery: Serves as a crucial intermediate in the research and development of peptide-based pharmaceuticals, prodrugs, and bioactive compounds.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic and research applications.
• Protecting Group Strategy: The Z (benzyloxycarbonyl) protecting group offers orthogonal protection that can be selectively removed under mild hydrogenolytic conditions.
• Chemical Biology Research: Employed in the synthesis of peptide substrates, inhibitors, and probes for studying enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	Z-Pro-Osu
CAS No.	3397-33-9
Molecular Formula	C15H18N2O6
Molecular Weight	322.32 g/mol
Synonyms	N-Carbobenzoxy-L-proline N-hydroxysuccinimide ester; Z-L-Proline N-succinimidyl ester; Cbz-Pro-OSu; Nα-Cbz-L-proline N-hydroxysuccinimide ester; Benzyloxycarbonyl-L-proline N-hydroxysuccinimide ester; N-(Benzyloxycarbonyl)-L-proline succinimidyl ester; NSC 334481; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)oxy)succinimidyl) pyrrolidine-2-carboxylate (common misnomer variant).
EINECS	Contact for details

Quality Control

Our Z-Pro-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and chiral purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.