Description

n-Trifluoroacetylglycine, n-Succinimidyl Ester is a highly reactive, activated ester derivative used for the selective modification of primary amines. This compound is a critical reagent for introducing the trifluoroacetyl (TFA) protecting group, which is prized for its stability under acidic conditions and its ease of removal under mild basic conditions. It is essential for researchers and manufacturers in pharmaceutical development, peptide synthesis, and bioconjugation, where precise and stable amine protection is required.

Application

• Peptide Synthesis: As an amine-protecting reagent for glycine and other amino acids during solid-phase or solution-phase peptide synthesis.
• Bioconjugation & Labeling: For the stable modification of proteins, antibodies, or other biomolecules at lysine residues or the N-terminus.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Protecting Group Chemistry: Specifically for introducing the trifluoroacetyl (TFA) group, which offers orthogonal protection strategies in multi-step syntheses.
• Cross-linking Agent: Used in the preparation of affinity chromatography resins and other immobilized ligand systems.
• Material Science: For the surface functionalization of polymers and nanomaterials with amine-reactive groups.

Basic Information

Product Name	n-Trifluoroacetylglycine, n-Succinimidyl Ester
CAS No.	3397-30-6
Molecular Formula	C8H7F3N2O5
Molecular Weight	268.15 g/mol
Synonyms	N-(Trifluoroacetyl)glycine N-hydroxysuccinimide ester; N-TFA-Glycine-OSu; 2,5-Dioxopyrrolidin-1-yl 2-(2,2,2-trifluoroacetamido)acetate; Glycine, N-(trifluoroacetyl)-, 2,5-dioxo-1-pyrrolidinyl ester; N-Trifluoroacetylglycine succinimidyl ester; TFA-Gly-OSu; NSC 334898; Trifluoroacetylglycine N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetylglycine, n-Succinimidyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and commercial synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.