Description

Succinimido (S)-2-[(tert-Butoxycarbonyl)Amino]Propionate is a high-purity, chiral N-hydroxysuccinimide (NHS) ester derivative, widely recognized as a key building block in advanced organic synthesis. Its primary value lies in its role as a reactive intermediate for the efficient, racemization-free introduction of the Boc-protected L-alanine moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors, particularly for the synthesis of peptide-based drugs, prodrugs, and labeled biomolecules where stereochemical integrity is paramount.

Application

• Peptide Synthesis: A crucial reagent for the solid-phase and solution-phase synthesis of complex peptides, enabling the incorporation of Boc-L-Ala.
• Bioconjugation & Labeling: Used to create stable amide bonds for attaching peptides, proteins, or other amine-containing compounds to surfaces, polymers, or fluorescent probes.
• Prodrug Development: Serves as an intermediate in designing prodrugs that improve the pharmacokinetic properties of active pharmaceutical ingredients (APIs).
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and cellular processes through site-specific modification.
• Material Science: Employed in the functionalization of biomaterials and polymers to introduce bioactive peptide sequences.
• Antibody-Drug Conjugate (ADC) Payload Linkage: Facilitates the construction of linker-payload systems in targeted cancer therapies.

Basic Information

Product Name	Succinimido (S)-2-[(tert-Butoxycarbonyl)Amino]Propionate
CAS No.	3392-05-0
Molecular Formula	C12H18N2O6
Molecular Weight	286.28 g/mol
Synonyms	Boc-L-Alanine N-Hydroxysuccinimide Ester; N-(tert-Butoxycarbonyl)-L-alanine N-succinimidyl ester; Boc-L-Ala-OSu; Boc-L-Alanine succinimidyl ester; N-Boc-L-alanine N-hydroxysuccinimide ester; Nα-Boc-L-alanine N-hydroxysuccinimide ester; (S)-2-((tert-Butoxycarbonyl)amino)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; 1-[(2S)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]propanoyl]oxy]pyrrolidine-2,5-dione
EINECS	Contact for details

Quality Control

Our Succinimido (S)-2-[(tert-Butoxycarbonyl)Amino]Propionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.