Description

Z-Ile-Osu CAS NO 3391-99-9 is a protected amino acid derivative, specifically the N-benzyloxycarbonyl (Z) protected form of isoleucine activated as an N-hydroxysuccinimide (Osu) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and selective formation of peptide bonds. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers involved in producing peptides for therapeutic, diagnostic, and biochemical research applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled, racemization-free incorporation of isoleucine into peptide chains.
• Pharmaceutical Intermediates: Key raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used to label proteins, antibodies, or other biomolecules with isoleucine residues or peptide tags under mild conditions.
• Biochemical Research: Synthesis of custom peptides for structure-activity relationship (SAR) studies, enzyme substrates, or inhibitors.
• Combinatorial Chemistry: Building block for generating diverse peptide libraries used in high-throughput screening for drug discovery.
• Material Science: Precursor for synthesizing peptide-polymer conjugates or bio-inspired materials.

Basic Information

Product Name	Z-Ile-Osu
CAS No.	3391-99-9
Molecular Formula	C17H22N2O6
Molecular Weight	350.37 g/mol
Synonyms	N-Cbz-Isoleucine N-Hydroxysuccinimide Ester; Nα-Benzyloxycarbonyl-L-isoleucine N-Succinimidyl Ester; Z-L-Isoleucine OSuc; Z-Ile-OSu; Cbz-Ile-OSu; N-Carbobenzoxy-L-isoleucine N-hydroxysuccinimide ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-methylpentanoic acid 2,5-dioxopyrrolidin-1-yl ester; Benzyl (1-((2,5-dioxopyrrolidin-1-yl)oxy)-3-methyl-1-oxopentan-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our Z-Ile-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.