Description

1,4-Dihydropyridine is a versatile heterocyclic organic compound that serves as a fundamental building block in medicinal chemistry and advanced material synthesis. Its core value lies in its role as a privileged scaffold for developing calcium channel blockers and other pharmacologically active agents. This intermediate is essential for research and production facilities in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients or optimize synthetic routes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nifedipine, amlodipine, and other 1,4-dihydropyridine-class calcium channel blockers for cardiovascular therapeutics.
• Organic Synthesis Building Block: Used in constructing complex heterocyclic compounds for drug discovery and material science research.
• Agrochemical Research: Employed as a core structure in developing novel pesticides and herbicides.
• Catalyst and Ligand Component: Utilized in the preparation of ligands for asymmetric catalysis and other organometallic applications.
• Academic & R&D: Fundamental compound for studying redox chemistry, hydrogenation reactions, and heterocyclic chemistry in university and corporate laboratories.

Basic Information

Product Name	1,4-Dihydropyridine
CAS No.	3337-17-5
Molecular Formula	C5H7N
Molecular Weight	81.12 g/mol
Synonyms	1,4-DHP; DHP; 1,4-Dihydro-pyridine; Pyridine, 1,4-dihydro-; 1,4-Dihydropyridine ring; Dihydropyridine scaffold; Hantzsch dihydropyridine precursor; 1,4-Dihydropyridine base structure
EINECS	222-082-1

Quality Control

Our 1,4-Dihydropyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles for each lot. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.