Description

Butanedioic Acid, 2,3-Dihydroxy- (2R,3R)-, Monomethyl Ester CAS NO 3333-46-8 is a high-purity chiral building block and intermediate, specifically the monomethyl ester of (2R,3R)-tartaric acid. This compound is valued for its role in asymmetric synthesis, serving as a key precursor for catalysts, ligands, and active pharmaceutical ingredients (APIs). It is essential for manufacturers and research institutions in the pharmaceutical, agrochemical, and fine chemical sectors requiring enantiomerically pure intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and drug candidates.
• Catalyst & Ligand Synthesis: Used to manufacture chiral catalysts and ligands for asymmetric hydrogenation and other stereoselective reactions.
• Fine Chemical Production: Serves as a building block for high-value specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Agrochemical Research: Employed in developing chiral pesticides and herbicides where biological activity is stereospecific.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.
• Resolution Agent: Can be utilized in the resolution of racemic mixtures due to its chiral nature.

Basic Information

Product Name	Butanedioic Acid, 2,3-Dihydroxy- (2R,3R)-, Monomethyl Ester
CAS No.	3333-46-8
Molecular Formula	C5H8O6
Molecular Weight	164.11 g/mol
Synonyms	(2R,3R)-2,3-Dihydroxysuccinic Acid Monomethyl Ester; (R,R)-Tartaric Acid Monomethyl Ester; L-(+)-Tartaric Acid Monomethyl Ester; Monomethyl (2R,3R)-Tartrate; Methyl (2R,3R)-2,3-Dihydroxybutanedioate; Methyl L-Tartrate; 3333-46-8; (2R,3R)-(-)-2,3-Dihydroxysuccinic Acid 1-Methyl Ester
EINECS	222-074-4

Quality Control

Our Butanedioic Acid, 2,3-Dihydroxy- (2R,3R)-, Monomethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling by HPLC, to ensure it meets exacting standards for research and industrial use. A Certificate of Analysis (COA) detailing specific results for purity, enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.