Description

n-Cbz-L-Proline p-Nitrophenyl Ester is a high-purity, protected amino acid derivative widely used as a key synthetic intermediate. This compound is specifically designed for peptide coupling reactions, offering excellent reactivity and selectivity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A crucial activated ester intermediate for the efficient coupling of Cbz-protected L-proline in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Research: Used in the research and development of proline-containing peptide drugs, prodrugs, and enzyme inhibitors.
• Bioconjugation: Serves as a reagent for the site-specific modification of biomolecules, enabling the creation of peptide-protein conjugates.
• Chemical Biology: Employed in the synthesis of peptide probes and tools for studying biological processes and protein-protein interactions.
• API Manufacturing: Acts as a key raw material in the scalable production of complex peptide Active Pharmaceutical Ingredients (APIs) under GMP conditions.
• Academic Research: A standard reagent in university and institutional laboratories for organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	n-Cbz-L-Proline p-Nitrophenyl Ester
CAS No.	3304-54-9
Molecular Formula	C19H18N2O6
Molecular Weight	370.36 g/mol
Synonyms	Carbobenzoxy-L-proline p-nitrophenyl ester; N-Carbobenzyloxy-L-proline 4-nitrophenyl ester; Z-L-Proline ONp ester; (S)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid 4-nitrophenyl ester; N-[(Benzyloxy)carbonyl]-L-proline 4-nitrophenyl ester; L-Proline, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; CBZ-L-Pro-ONp; Z-Pro-ONp
EINECS	Contact for details

Quality Control

Our n-Cbz-L-Proline p-Nitrophenyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to maintain purity and reactivity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.