Description

Estradiol 3,17-Disulfate is a sulfated metabolite of the primary female sex hormone, estradiol. This compound is of significant interest in biochemical research and pharmaceutical development due to its role in hormone metabolism and potential as a biomarker. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in endocrinology, metabolism studies, and the development of analytical standards or diagnostic kits. The product is supplied under stringent quality controls to ensure batch-to-batch consistency for critical applications.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in studies of estrogen metabolism, sulfation pathways, and steroid hormone biology.
• Diagnostic Kit Development: Serves as a critical calibrator or antigen in the development and validation of immunoassays (ELISA, RIA) for hormone level testing.
• Pharmaceutical Impurity Profiling: Employed as an analytical reference standard for the identification and quantification of related substances in estradiol-based drug products.
• Metabolite Studies: Essential for in vitro and in vivo research investigating the pharmacokinetics, bioavailability, and clearance of estradiol and its derivatives.
• Enzyme Activity Assays: Used as a specific substrate for studying the activity of sulfotransferase and sulfatase enzymes.

Basic Information

Product Name	Estradiol 3,17-Disulfate
CAS No.	3233-70-3
Molecular Formula	C18H22O10S2
Molecular Weight	462.49 g/mol
Synonyms	Estradiol 3,17-Disulfate; Estradiol Disulfate; E2-3,17-DS; 1,3,5(10)-Estratrien-3,17β-diol 3,17-Disulfate; 17β-Estradiol 3,17-Disulfate; Estra-1,3,5(10)-triene-3,17β-diol 3,17-disulfate; NSC 113986
EINECS	Contact for details

Quality Control

Our Estradiol 3,17-Disulfate is manufactured and tested to meet the exacting standards required for research and diagnostic applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.