Description

4-Bis(2-Chlorethyl)-Amino-L-Phenylalanine Hydrochloride is a specialized nitrogen mustard derivative of the amino acid phenylalanine, primarily utilized as a key synthetic intermediate in pharmaceutical research and development. This compound matters for its role in the synthesis of targeted chemotherapeutic agents and other biologically active molecules. It is needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers focused on oncology drug discovery and advanced medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of alkylating agent prodrugs and targeted cancer therapeutics.
• Oncology Research: Used in preclinical studies to develop novel chemotherapeutic compounds that leverage the nitrogen mustard pharmacophore.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the creation of new chemical entities.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) due to its reactive chloroethyl groups and amino acid backbone.
• Biochemical Research: Employed in studies investigating DNA alkylation mechanisms and cellular response to alkylating agents.

Basic Information

Product Name	4-Bis(2-Chlorethyl)-Amino-L-Phenylalanine Hydrochloride
CAS No.	3223-07-2
Molecular Formula	C₁₃H₁₉Cl₃N₂O₂
Molecular Weight	341.66 g/mol
Synonyms	L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride; DL-4-[Bis(2-chloroethyl)amino]phenylalanine hydrochloride; Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride, L-; L-4-[Bis(2-chloroethyl)amino]phenylalanine hydrochloride; NSC 104469; 4-[N,N-Bis(2-chloroethyl)amino]-L-phenylalanine HCl
EINECS	Contact for details

Quality Control

Our 4-Bis(2-Chlorethyl)-Amino-L-Phenylalanine Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.