Description

1-Trimethylsilylmethanol is a versatile organosilicon compound featuring both a silyl protecting group and a reactive hydroxyl functionality. This unique structure makes it a valuable synthetic intermediate and silylating agent in advanced organic synthesis. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Silyl Protecting Group: Used to protect hydroxyl groups in multi-step organic synthesis, particularly for sensitive or complex molecules in pharmaceutical R&D.
• Precursor to Silyl Ethers: Serves as a key starting material for the preparation of various trimethylsilyl (TMS) ether derivatives.
• Cross-Coupling Reactions: Employed as a reagent in palladium-catalyzed cross-coupling reactions to introduce functionalized fragments.
• Surface Modification Agent: Utilized in material science to modify the surface properties of silica, glass, or other oxides, enhancing hydrophobicity.
• Polymer Chemistry Intermediate: Acts as a monomer or chain-transfer agent in the synthesis of specialty silicones and hybrid organic-inorganic polymers.
• Ligand Synthesis: Used in the preparation of ligands for catalysis and coordination chemistry.

Basic Information

Product Name	1-Trimethylsilylmethanol
CAS No.	3219-63-4
Molecular Formula	C4H12OSi
Molecular Weight	104.22 g/mol
Synonyms	(Hydroxymethyl)trimethylsilane; Trimethylsilylmethanol; (Trimethylsilyl)methanol; TMSM; Silanol, trimethyl-, methyl ether; Hydroxymethyl(trimethyl)silane; NSC 518826
EINECS	221-749-1

Quality Control

Our 1-Trimethylsilylmethanol is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO quality standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.