Description

Z-D-Gln-Onp CAS NO 3196-71-2 is a protected amino acid derivative, specifically N-α-(Z)-D-glutamine p-nitrophenyl ester. This compound serves as a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient, racemization-free incorporation of D-glutamine into peptide chains.
• Solution-Phase Peptide Coupling: A key reagent for the segment condensation and fragment coupling strategies in complex peptide assembly.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for biochemical studies.
• Academic & Industrial R&D: A fundamental tool in organic and medicinal chemistry laboratories for exploring peptide structure-activity relationships.
• Synthesis of Unnatural Amino Acids: Acts as a precursor for creating specialized, non-proteinogenic amino acid analogs.

Basic Information

Product Name	Z-D-Gln-Onp
CAS No.	3196-71-2
Molecular Formula	C19H19N3O7
Molecular Weight	401.37 g/mol
Synonyms	N-α-Carbobenzoxy-D-glutamine p-nitrophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-5-((4-nitrophenoxy)carbonyl)pentanoic acid; Z-D-Glutamine p-nitrophenyl ester; D-Glutamine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; CBZ-D-Gln-ONp; N-CBZ-D-glutamine 4-nitrophenyl ester; Benzyloxycarbonyl-D-glutamine p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-D-Gln-Onp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reproducible performance in your processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.