Description

Diethyl (Chloromethyl)Phosphonate is a versatile organophosphorus compound that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both a phosphonate ester and a reactive chloromethyl group, makes it an invaluable reagent for introducing the phosphonate moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bisphosphonate drugs for treating osteoporosis and other bone disorders.
• Agrochemical Synthesis: Building block for creating novel herbicides, insecticides, and plant growth regulators containing phosphonate groups.
• Flame Retardant Production: Used in the manufacture of reactive and additive flame retardants for polymers and textiles.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing phosphonate-based ligands used in coordination chemistry and catalysis.
• Material Science: Intermediate for producing surface modifiers, adhesion promoters, and specialty monomers.
• Organic Synthesis Reagent: Employed in Horner-Wadsworth-Emmons (HWE) olefination reactions and other carbon-carbon bond forming processes.

Basic Information

Product Name	Diethyl (Chloromethyl)Phosphonate
CAS No.	3167-63-3
Molecular Formula	C5H12ClO3P
Molecular Weight	186.57 g/mol
Synonyms	(Chloromethyl)phosphonic Acid Diethyl Ester; Diethyl Chloromethylphosphonate; Diethyl Phosphorochloridate; (Chloromethyl)diethoxyphosphine Oxide; Diethyl P-Chloromethylphosphonate; EINECS 221-627-5; NSC 88184; Chloromethylphosphonic Acid Diethyl Ester
EINECS	221-627-5

Quality Control

Our Diethyl (Chloromethyl)Phosphonate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' needs for reliable, high-grade chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.190 - 1.210 g/mL
Refractive Index (n20D)	1.438 - 1.442

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.