Description

8-Quinolinylisocyanide (8Ci) is a versatile isocyanide derivative of quinoline, serving as a critical building block in advanced organic synthesis. Its unique structure makes it an invaluable reagent for the construction of complex heterocyclic frameworks and functional materials. This high-purity intermediate is essential for research and development in pharmaceutical chemistry, agrochemical discovery, and coordination chemistry for catalyst design.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those with quinoline-based pharmacophores for antimicrobial or anticancer activity.
• Ligand in Coordination Chemistry: Used to prepare specialized metal-organic complexes and catalysts for asymmetric synthesis and polymerization reactions.
• Agrochemical Research: Building block for developing new active ingredients in crop protection agents.
• Material Science: Employed in the synthesis of organic semiconductors, fluorescent dyes, and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: Fundamental reagent for methodological development in isocyanide-based multicomponent reactions (e.g., Ugi, Passerini).

Basic Information

Product Name	8-Quinolinylisocyanide (8Ci)
CAS No.	3101-17-5
Molecular Formula	C10H6N2
Molecular Weight	154.17 g/mol
Synonyms	8-Isocyanoquinoline; Quinolin-8-yl isocyanide; 8-Quinoline isocyanide; 8-Quinolinyl isocyanide; 8-Cyanoisoquinoline (common misnomer); 8-Quinolyisocyanide; 8-Quinolyl isonitrile
EINECS	221-456-1

Quality Control

Our 8-Quinolinylisocyanide (8Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system supports compliance with global regulatory requirements for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.