Description

Ethyl 3-Phenyl-L-Alaninate is a protected amino acid ester derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a stereochemically defined phenylalanine side chain while offering the versatility of an ethyl ester protecting group, which can be selectively manipulated under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediates: Key chiral synthon for the synthesis of peptide drugs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate protected L-phenylalanine analogs into peptide chains.
• Proteomics Research: Serves as a building block for creating custom amino acid derivatives and probes in biochemical research.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to construct complex chiral molecules.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories.

Basic Information

Product Name	Ethyl 3-Phenyl-L-Alaninate
CAS No.	3081-24-1
Molecular Formula	C₁₁H₁₅NO₂
Molecular Weight	193.24 g/mol
Synonyms	L-Phenylalanine ethyl ester; Ethyl L-phenylalaninate; (S)-2-Amino-3-phenylpropanoic acid ethyl ester; Ethyl (S)-2-amino-3-phenylpropanoate; Ethyl α-amino-β-phenylpropionate; H-Phe-OEt; Fmoc-Phe-OEt (when protected); NSC 3349
EINECS	221-369-5

Quality Control

Our Ethyl 3-Phenyl-L-Alaninate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to guarantee supply consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Solubility	Soluble in common organic solvents (e.g., methanol, ethanol, DMF, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.