Description

Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate is a versatile fluorinated organic ester that serves as a critical chiral building block and intermediate in advanced chemical synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl moiety, enables precise molecular modifications essential for developing high-value compounds. This product is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring fluorinated synthons.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving dielectric anisotropy and performance.
• Fluorinated Polymer Modifier: Employed to introduce fluorine into polymer chains, enhancing material properties like chemical resistance, thermal stability, and surface characteristics.
• Asymmetric Catalysis & Chiral Resolution: Utilized as a substrate or resolving agent in the development of chiral catalysts and separation processes.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the 3-hydroxy-4,4,4-trifluorobutyl fragment into more complex molecular architectures.

Basic Information

Product Name	Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate
CAS No.	372-30-5
Molecular Formula	C6H9F3O3
Molecular Weight	186.13 g/mol
Synonyms	Ethyl 3-Hydroxy-4,4,4-Trifluorobutanoate; 4,4,4-Trifluoro-3-hydroxybutyric Acid Ethyl Ester; 3-Hydroxy-4,4,4-trifluorobutanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoro-3-hydroxybutyrate; (R/S)-Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate; 3-Hydroxy-4,4,4-trifluorobutyric Acid Ethyl Ester; TFBE
EINECS	206-757-6

Quality Control

Our Ethyl 3-Hydroxy-4,4,4-Trifluorobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistent performance as a synthesis intermediate. Standard quality parameters include assay, enantiomeric excess (where applicable), and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is moisture-sensitive; ensure containers are kept tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.