Description

n-Butyl Trifluoroacetate is a versatile fluorinated ester widely used as a key reagent and building block in organic synthesis. Its primary value lies in its role as a trifluoroacetylating agent and a protected form of trifluoroacetic acid, enabling the introduction of the trifluoromethyl group into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the development of novel active ingredients and specialty chemicals with enhanced properties.

Application

• Pharmaceutical Intermediate: A crucial reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoroacetate moiety can enhance biological activity.
• Peptide Chemistry: Serves as a protecting group for amino acids during peptide synthesis, especially where standard protecting groups are not suitable.
• Organic Synthesis Reagent: Acts as a trifluoroacetylating agent for alcohols, amines, and other nucleophiles in fine chemical and material science research.
• Solvent for Specialized Reactions: Employed as a polar, aprotic solvent in reactions requiring specific solubility properties or as a reaction medium for fluorination chemistry.
• Liquid Crystal & Polymer Precursor: Utilized in the synthesis of fluorinated monomers and intermediates for high-performance polymers and liquid crystal displays (LCDs).

Basic Information

Item	Details
Product Name	n-Butyl Trifluoroacetate
CAS No.	367-64-6
Molecular Formula	C6H9F3O2
Molecular Weight	170.13 g/mol
Synonyms	Butyl Trifluoroacetate; Trifluoroacetic Acid Butyl Ester; n-Butyl Trifluoroethanoate; 1-Butyl Trifluoroacetate; Butyl Ester of Trifluoroacetic Acid; TFA Butyl Ester; n-BuTFA; Butyl 2,2,2-Trifluoroacetate
EINECS	206-699-7

Quality Control

Our n-Butyl Trifluoroacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases, strong oxidizing agents, and strong reducing agents. Due to its nature as a strong acid/organic solvent and highly volatile liquid, ensure containers are kept tightly sealed to prevent evaporation and moisture ingress. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.335 - 1.345
Density (20°C)	1.18 - 1.22 g/mL
Boiling Point	Approx. 100-102°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.