Description

2-Bromo-4,4,4-Trifluorobutyric Acid Ethyl Ester is a versatile fluorinated organic building block of significant importance in advanced chemical synthesis. Its molecular structure, featuring both bromine and trifluoromethyl groups, makes it a critical intermediate for introducing fluorine atoms into target molecules, thereby modifying their physical, chemical, and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modification: Incorporated to create specialty fluoropolymers with enhanced chemical resistance, low surface energy, and improved weatherability.
• Organic Synthesis Reagent: Utilized in nucleophilic substitution and coupling reactions to construct complex fluorinated molecular architectures in R&D settings.

Basic Information

Product Name	2-Bromo-4,4,4-Trifluorobutyric Acid Ethyl Ester
CAS No.	367-33-9
Molecular Formula	C6H8BrF3O2
Molecular Weight	249.03 g/mol
Synonyms	Ethyl 2-Bromo-4,4,4-trifluorobutanoate; 4,4,4-Trifluoro-2-bromobutanoic Acid Ethyl Ester; 2-Bromo-4,4,4-trifluorobutanoic Acid Ethyl Ester; Butanoic acid, 2-bromo-4,4,4-trifluoro-, ethyl ester; Ethyl α-Bromo-γ,γ,γ-trifluorobutyrate; NSC 404080; BTFBE
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,4,4-Trifluorobutyric Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.420
Density (20°C)	1.55 - 1.65 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.