Description

2-Methoxyestradiol is a potent, naturally occurring metabolite of estradiol with significant biological activity. This compound is of high interest in pharmaceutical research and development due to its unique anti-proliferative and anti-angiogenic properties. It serves as a critical reference standard and key intermediate for researchers and manufacturers in the life sciences, oncology, and endocrinology sectors.

Application

• Pharmaceutical Research: As a reference standard for analytical method development and validation in pharmacokinetic and metabolic studies.
• Drug Discovery: A key intermediate in the synthesis of novel therapeutic agents targeting hormone-dependent pathways.
• Oncology Studies: Investigation of its role as a potential anti-cancer agent due to its ability to inhibit tumor growth and angiogenesis.
• Biochemical Research: Used in cell culture and in vitro assays to study estrogen metabolism and receptor interactions.
• Academic Research: Fundamental studies in endocrinology, cell biology, and molecular pharmacology.

Basic Information

Item	Detail
Product Name	2-Methoxyestradiol
CAS No.	362-07-2
Molecular Formula	C19H26O3
Molecular Weight	302.41 g/mol
Synonyms	2-Methoxyestra-1,3,5(10)-triene-3,17β-diol; 2-MeOE2; NSC-659853; 17β-Hydroxy-2-methoxyestra-1,3,5(10)-trien-3-ol; Panzem; 2-Methoxy-17β-estradiol
EINECS	Contact for details

Quality Control

Our 2-Methoxyestradiol is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting key parameters such as assay, related substances, and residual solvents are provided and available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.