Description

Methyl 3-Methoxy-2-(Trifluoromethyl)Propanoate CAS NO 359-88-6 is a specialized fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl and methoxy substituents, enabling the construction of complex molecules with tailored properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated components in advanced display technologies and dielectric fluids.
• Polymer Modification: Incorporated as a monomer or modifier to introduce fluorine into polymer backbones, improving chemical resistance and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and nucleophilic substitutions to introduce the 2-(trifluoromethyl)propanoate moiety.
• Flavor & Fragrance Intermediate: Potential use in the synthesis of complex, high-value aroma chemicals where specific steric and electronic profiles are required.

Basic Information

Product Name	Methyl 3-Methoxy-2-(Trifluoromethyl)Propanoate
CAS No.	359-88-6
Molecular Formula	C6H9F3O3
Molecular Weight	186.13 g/mol
Synonyms	Methyl 3-Methoxy-2-(trifluoromethyl)propionate; 2-(Trifluoromethyl)-3-methoxypropionic Acid Methyl Ester; 3-Methoxy-2-(trifluoromethyl)propionic Acid Methyl Ester; Methyl β-Methoxy-β-trifluoromethylpropionate; Methyl 3-Methoxy-2-(trifluoromethyl)propanoate; Propanoic acid, 3-methoxy-2-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Methoxy-2-(Trifluoromethyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials such as strong bases and fluorides. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.365 - 1.375
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.