Description

4-Fluorophenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its primary value lies in its ability to introduce the versatile 4-fluorophenyl group into a wide array of molecular scaffolds, enabling the synthesis of complex intermediates. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where fluorinated aromatic compounds are critical for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating fluorinated active pharmaceutical ingredients (APIs), including potential CNS agents and anti-inflammatory drugs.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Production: Serves as a precursor for fluorinated aromatic cores that improve the performance of electronic display materials.
• Polymer Modification: Employed to incorporate fluorophenyl groups into polymer chains, altering thermal and chemical resistance properties.
• Cross-Coupling Reactions: A crucial reagent in Kumada, Negishi, and other transition-metal catalyzed cross-coupling reactions to form biaryl structures.
• Fine Chemical and Specialty Chemical Manufacturing: Used in custom synthesis and the production of complex fluorinated molecules for various high-value applications.

Basic Information

Item	Detail
Product Name	4-Fluorophenylmagnesium Bromide
CAS No.	352-13-6
Molecular Formula	C6H4FMgBr
Molecular Weight	199.30 g/mol
Synonyms	p-Fluorophenylmagnesium Bromide; (4-Fluorophenyl)magnesium Bromide; 1-Fluoro-4-(bromomagnesio)benzene; Magnesium, bromo(4-fluorophenyl)-; Grignard Reagent (4-Fluorophenyl); 4-FluorophenylMgBr; 4-FC6H4MgBr
EINECS	Contact for details

Quality Control

Our 4-Fluorophenylmagnesium Bromide is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay, and impurity profiles. Our quality system is designed to meet the exacting standards required for GMP-intermediate manufacturing and high-purity R&D.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, easily oxidized, and reacts violently with protic solvents. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area, away from moisture, heat, and ignition sources. For solutions, store at recommended temperatures (often 2-8°C or as specified) and monitor pressure.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown solution
Concentration	Typically 0.5 M to 2.0 M in THF or Diethyl Ether
Assay (Titration)	≥ 95% (as C6H4FMgBr)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.