Description

4-Fluoro-1-Naphthylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its core value lies in introducing the versatile 4-fluoro-1-naphthyl moiety into target molecules, enabling the creation of advanced intermediates for pharmaceuticals and specialty chemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex aromatic frameworks.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the development of active pharmaceutical ingredients (APIs), particularly those containing fluorinated naphthalene structures.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides where the fluoronaphthyl group enhances biological activity and stability.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic electronic materials, including charge-transport layers and emitters for organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands for transition metal catalysis and other organometallic complexes.
• Fine Chemical & Flavor/Fragrance Synthesis: Facilitates the construction of complex aromatic molecules used in high-value fine chemicals and aroma compounds.
• Academic & Contract Research: A vital tool for methodological development and exploratory synthesis in university laboratories and contract research organizations (CROs).

Basic Information

Product Name	4-Fluoro-1-Naphthylmagnesium Bromide
CAS No.	17318-06-8
Molecular Formula	C₁₀H₆FMgBr
Molecular Weight	249.36 g/mol
Synonyms	1-(Bromomagnesio)-4-fluoronaphthalene; 4-Fluoronaphthalen-1-ylmagnesium Bromide; Magnesium, bromo(4-fluoro-1-naphthalenyl)-; (4-Fluoro-1-naphthyl)magnesium Bromide; 4-Fluoro-1-naphthalenylmagnesium Bromide; Grignard Reagent 4-Fluoro-1-NaphthylMgBr
EINECS	Contact for details

Quality Control

Every batch of our 4-Fluoro-1-Naphthylmagnesium Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. We employ rigorous analytical controls, including titration for Grignard concentration and GC/HPLC analysis for solvent and impurity profiles, to guarantee consistency and performance. A comprehensive Certificate of Analysis (COA) detailing concentration, assay, and solvent specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This reagent is highly volatile, easily oxidized, and must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures of 2°C to 8°C. The container should be kept in a cool, dry, well-ventilated area, away from heat, sparks, and incompatible materials such as strong acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in specified solvent)	0.5 M - 1.0 M (Typical, custom available)
Assay (by Titration)	≥ 95%
Solvent	Typically Tetrahydrofuran (THF) or Diethyl Ether
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.