Description

4-Fluorobenzylmagnesium Chloride is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry. Its core value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, introducing the valuable 4-fluorobenzyl group into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated benzyl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine substitution enhances biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and organometallic catalysts used in cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials.
• Fine Chemical Production: Integral for the custom synthesis of complex fluorinated aromatic compounds for various industrial applications.
• Academic & R&D Laboratories: A fundamental reagent for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Item	Detail
Product Name	4-Fluorobenzylmagnesium Chloride
CAS No.	1643-73-8
Molecular Formula	C7H6ClFMg
Molecular Weight	168.87 g/mol
Synonyms	(4-Fluorophenyl)methylmagnesium Chloride; 1-(Chloromagnesio)methyl-4-fluorobenzene; p-Fluorobenzylmagnesium Chloride; 4-Fluorobenzyl Chloromagnesio; Magnesium, chloromethyl(4-fluorophenyl)-; Grignard Reagent (4-Fluorobenzyl); 4-Fluoro-Benzylmagnesium Chloride Solution
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzylmagnesium Chloride is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, titration assay, and impurity profile. Our quality system is designed to meet the exacting standards required for GMP intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a highly volatile and easily oxidized Grignard reagent, it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures of 2°C to 8°C. The container should be kept in a cool, dry, well-ventilated area away from moisture, heat, and incompatible materials.

Specification

Item	Specification
Appearance	Clear solution, colorless to light yellow
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom)
Assay (by Titration)	≥ 95.0%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.